This document provides practical guidance for advocates, policymakers and civil society actors on how international and regional human rights systems can be used to accelerate the elimination of female genital mutilation (FGM). The publication explains key accountability mechanisms, such as treaty bodies, special procedures, regional human rights courts and national human rights institutions, and demonstrates how they can be leveraged to strengthen laws, policies and access to justice for girls at risk and survivors. Through concrete examples and advocacy strategies, the compendium supports governments, activists and partners in using human rights frameworks more effectively to hold institutions accountable, advance gender equality and drive coordinated action to end FGM.